As of 12 October 2020, the global pandemic crisis of COVID-19 has seen a reported number of almost 38 millions cases and a total global deaths of more than 1 million people. This pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lack of targeted medications and vaccines, has forced the scientific world to search for new antiviral formulations. Many plant-derived natural compounds (polyphenols) might provide a starting point for the research on the use of plant extracts in coronavirus treatment and intervention. Antivirus polyphenolic drugs can inhibit coronavirus enzymes, which are essential for virus replication and infection. Nanoparticles have a great interest in acting as nanocarriers, to increase the concentration of drugs at the desired site. A nanocomplex composed of encapsulation of catechin (a polyphenol extracted from Mas Cotek’s leaves) and hydroxyapatite (HAp) nanoparticles as a drug carrier were developed. Hydroxyapatite nanoparticles protect the catechin from degradation along the respiratory passageways and catechin once being unencapsulated in the lungs, will bind to the viral spike protein (S-Protein) of the coronavirus and the cognate host cell receptor ACE 2, which will eventually inhibit the coronavirus from replicating itself. This will eventually intervene in the infection of COVID-19.
Created by: Associate Professor Dr. Midhat Nabil Ahmad Salimi, Associate Professor Dr. Muhammad Syarhabil Ahmad, Rafida Khalid Ahmad